In vitro models of sex chromosomal aneuploidies to investigate the developmental consequences of supernumerary sex chromosomes
Investigating the mechanisms that regulate primordial germ cells (PGC) differentiation and fertility in Klinefelter syndrome
Using an iPSC + CRISPR Platform to Investigate Disease-Related Pathology
3D Reconstruction and AR/VR visualization of CNS components in Klinefelter Syndrome Brain Organoids
Investigating the epigenetic regulation using hESCs, iPSCs, and brain organoid systems.
Molecular Characterization of X-Linked Gene Dosage in Klinefelter Syndrome and High-Grade X Aneuploidies
Study the effect of having extra X chromosomes affects the interplay between epigenomics and transcription
Explores the crosstalk between dosage-related and differentially expressed genes and how this interaction influences cell fate determination.