Human stem cell-based approach to study model metabolic disorders
The modern society is afflicted by a pandemic increase in metabolic disorders and unraveling the transcriptional and the epigenetic mechanisms driving metabolic response to different stimuli has become an inescapable must to develop new therapeutic strategies.
We are seeking a highly motivated internship student to reproduce in vitro the differentiation of human embryonic stem cells (hESC) and patient-derived induced pluripotent stem cells (hiPSCs) into glucose sensitive cell types (hepatocytes, adiposcytes
and beta-pancreatic cells).
Role of chromatin modifiers in stem cell derived glucose-sensitive cell types
The understanding of the transcriptional and epigenetic mechanisms dysregulated in patients affected by metabolic disorders such as insulin resistance (IR) and type 2 diabetes mellitus (T2DM) is essential to derive efficient pharmacological approaches. We are seeking an outstanding internship student to work on a project focused on the study of the role of histone modifiers to the onset of metabolic disorders.