I am a Research Scientist in the STEMD laboratory, where I study the effects of sex chromosome overdosage on neuronal and cardiac development using in vitro models. My work has first been dedicated to the derivation of a cohort of X and Y aneuploid iPSCs obtained from patients with Klinefelter (47,XXY), and Jacobs (47,XYY) Syndromes, and high-grade X aneuploidies (48, XXXY and 49,XXXXY). In particular, I use iPSC-derived 3D brain organoids to investigate how sex gene expression imbalance alters the transcriptional, morphological, and electrophysiological properties of neuronal differentiation and the establishment of functional synaptic connectivity.
Veronica Astro.