The Stem Cell and DIsease Laboratory focuses on the use of human embryonic stem cells (hESCs) and patient-derived induced pluripotent stem cells (iPSCs) to model the onset and progression of human disorders linked to copy number variations “in a dish.” Prof. Adamo's team developed the largest cohort of Klinefelter syndrome (karyotype 47,XXY) and high-grade X aneuploid iPSCs (karyotype 48,XXXY and 49,XXXXY). We use this unique cellular model to study the molecular dysregulations associated with X chromosome aneuploidy during the earliest stages of human development.
Professor Adamo’s team combines reprogramming, organoid derivation, and genome editing techniques with a multi-omics approach to identify the transcriptional and epigenetic signatures underlying human diseases.
08 November, 2019CRG Grant Awarded to STEMD Lab
Congratulations to Professor Adamo and STEMD Lab members on the receipt of the CRG Grant
12 May, 2020KAUST Smart Health Initiative Seed Grant Awarded to STEMD Lab
Professor Adamo and his team have been awarded the KAUST Smart Health Initiative Seed Grant for their project entitled “An iPSC-based disease-modeling approach to study Klinefelter Syndrome in a unique cohort of Saudi patients”. This project will be executed in collaboration with a scientific team from King Abdulaziz University (KAU) in Jeddah.
23 April, 2020MSc Student Dalal Al-Farhan successfully defends her MSc Thesis
Congratulations to Dalal Al-Farhan on the successful defence of her MSc thesis entitled "Dissecting the Role of the Histone Demethylase KDM1B in Maintenance of Pluripotency and Differentiation of Human Embryonic Stem Cells". Dalal is the second masters student to graduate from Professor Adamo's group.
iPSC Based Disease Modeling