Antonio Adamo

Principal Investigator

Assistant Professor, Biological and Environmental Sciences and Engineering Division



Bld 2 Level 3 Room 3335

Research Interest

​Professor Adamo’s research interests focus on the study of the transcriptional and epigenetic mechanisms dysregulated in metabolic disorders such as Insulin Resistance (IR) and Type II Diabetes Mellitus (T2DM). His team relies on the use of the innovative reprogramming technique to derive induced pluripotent stem cells (iPSCs) from fibroblasts obtained from large cohorts of patients and healthy donors. iPSCs can be differentiated to virtually all cell types of the human body and therefore constitute an unprecedented cellular platform to model disease progression. Professor Adamo’s team combines reprogramming, next generation sequencing (NGS), genome editing and cellular biology techniques to identify the transcriptional and epigenetic signatures prognostic of metabolic diseases and to develop in vitro screening assays aimed to isolate chemical compounds able to revert these pathological signatures. ​

Selected Publications

    • ​Adamo A., Atashpaz S., Germain P.-L., Zanella M., D’Agostino G., Albertin V., Chenoweth J., Micale L., Fusco M., Unger C., Augello B., Palumbo O., Hamilton B., Carella M., Donti E., Pruneri G., Selicorni A., Biamino E., Prontera P., McKay R., Merla G. & Testa G. (2015) 7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages. Nat. Genetics 2015 Feb;47(2):132-41​.
    • Adamo A, Barrero MJ, Izpisúa Belmonte JC. (2011) LSD1 and pluripotency: a new player in the network. Cell Cycle 10(19): 3215-6.
    • Adamo A, Sesé B, Boue S, Castaño J, Paramonov I, Barrero MJ, Izpisúa Belmonte JC. (2011) LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nat Cell Biol 13(6): 652-60.
    • Zibetti C, Adamo A, Binda C, Forneris F, Toffolo E, Verpelli C, Ginelli E, Mattevi A, Sala C, Battaglioli E. (2010) Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system. J Neurosci 30(7): 2521-32.
    • Forneris F, Binda C, Adamo A, Battaglioli E, Mattevi A. (2007) Structural basis of LSD1-CoREST selectivity in histone H3 recognition. J Biol Chem 282 (28): 20070-4.​

    KAUST Affiliations

    Biological and Environmental Science and Engineering Division (BESE)

    KAUST Environmental Epigenetics Program (KEEP)

    KAUST Smart Health Initiative